Fioricet contains Butalbital, Acetaminophen, and caffeine. A lot of other pain relievers contain Butalbital, Acetaminophen, and caffeine too.
I can only list some common over the counter medicines that contain Acetaminophen: Actifed, Alka-Seltzer, Plus Liquid Gels, Anacin, Cepacol, Contac, Coricidin, Dayquil, Dimetapp, Dristan, Excedrin, Feverall …
Some prescriptions that contain acetaminophen are: Ultrace, Fioricet, Oxycodone, Endocet, Tylox …
You also must know what drugs contain Butalbital: Bupap, Phrenilin, Tencon, Cephadyn; Fioricet, Esgic, Esgic-Plus; Fioricet with Codeine, Floricet with Codeine, Phrenilin with Caffeine and Codeine; Axotal; Fiorinal, Butalbital Compound, Farbital, Idenal; Fiorinal with Codeine, Fiorinal with Codeine III, Ascomp with Codeine, Fiortal with Codeine.
When you take more than one pain killer, you must read very carefully about their components. Never exceed the max dosage of acetaminophen and butalbital of all the medicines you are taking. Normally All the packages sent to you have the drug introduction and doctor names and phone number. Read the drug introduction very carefully and never share the medicines with your sisters, your brothers, your parents, or any friends. Always do not let the children touch the medicines.
Please donot drink any alcohol (Ethanol) with your Fioricet Because Ethanol together with acetaminophen will cause serious side effects that affect your liver, and Ethanol together with Butalbital will cause side effects of dizziness, drowsiness.
Please don’t take herb while you are taking Fioricet. Even Vitamins will have some interaction with Fioricet.
Be honest to place the current medicines you are taking in the health questionnaire form. The doctor will check whether you are OK to take Fioricet. If they think your current drugs or herbs have some interaction with Fioricet, they will phone you to discuss the situation with you. So please always leave us the correct phone number. We will never call you to promote you anything.
Most frequently checked interactions
View interaction reports for Fioricet (acetaminophen / butalbital / caffeine) and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Advil (ibuprofen)
- Ambien (zolpidem)
- aspirin
- Ativan (lorazepam)
- baclofen
- caffeine
- clonazepam
- codeine
- Cymbalta (duloxetine)
- Excedrin (acetaminophen / aspirin / caffeine)
- Flexeril (cyclobenzaprine)
- gabapentin
- hydrocodone
- ibuprofen
- ibuprofen
- Imitrex (sumatriptan)
- Klonopin (clonazepam)
- levothyroxine
- Lexapro (escitalopram)
- lisinopril
- Lyrica (pregabalin)
- meloxicam
- naproxen
- Norco (acetaminophen / hydrocodone)
- omeprazole
- oxycodone
- Percocet (acetaminophen / oxycodone)
- prednisone
- Suboxone (buprenorphine / naloxone)
- Topamax (topiramate)
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
Fioricet (acetaminophen / butalbital / caffeine) disease interactions
There are 25 disease interactions with Fioricet (acetaminophen / butalbital / caffeine) which include:
- alcoholism
- liver disease
- acute alcohol intoxication
- drug dependence
- liver disease
- porphyria
- rash
- respiratory depression
- cardiac disease
- hypertension
- liver disease
- PUD
- PKU
- adrenal insufficiency
- depression
- hematologic toxicity
- osteomalacia
- paradoxical reactions
- cardiotoxicity
- bipolar disorders
- psychiatric disorders
- psychotic disorders
- renal dysfunction
- seizure disorders
- GERD
FIORICET (Brand for BUTALBITAL-ACETAMINOPHEN-CAFFE) Lifestyle Interactions
Butalbital 50mg, Acetaminophen 300mg, Caffeine 40mg, Oral capsule
Alcohol
· Severity: Major
· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication increases the risk of liver injury. Contact your care team right away if you experience right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, or unusual weakness or fatigue.
· Notes for Professionals: The risk of developing hepatotoxicity from acetaminophen appears to be increased in patients who regularly consume alcohol. Patients who drink more than 3 alcohol-containing drinks a day and take acetaminophen are at increased risk of developing hepatotoxicity. Acute or chronic alcohol use increases acetaminophen-induced hepatotoxicity by inducing CYP2E1 leading to increased formation of the hepatotoxic metabolite of acetaminophen. Also, chronic alcohol use can deplete liver glutathione stores. Administration of acetaminophen should be limited or avoided altogether in patients with alcoholism or patients who consume alcohol regularly.
Caffeine-containing Foods/Beverages
· Severity: Moderate
· Notes for Consumers: Caffeine may cause sleeplessness, so if you are taking a Barbiturate to help you sleep, you may wish to avoid taking caffeine and caffeine-containing foods like colas, coffee, teas, or chocolates within several hours prior to bedtime. Barbiturates may also decrease the actions of Caffeine; if you have a high intake of caffeinated foods or beverages you may experience a headache or irritability from decreased caffeine levels while taking these drugs until your body adjusts. If you take Caffeine for other purposes, notify your health care provider if you think Caffeine is not working as well for you.
· Notes for Professionals: Caffeine has been reported to increase the metabolism of barbiturates, and barbiturates increase caffeine elimination. Higher caffeine doses may be needed after barbiturate administration.
Cannabis
· Severity: Major
· Notes for Consumers: Discuss cannabis use with your care team. The effects of cannabis may be altered if used with your medication. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.
· Notes for Professionals: Advise patients to avoid cannabis use during barbiturate treatment due to the risk for additive CNS depression and other adverse reactions. Concomitant use may also decrease the concentration of some cannabinoids and alter their effects. The cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are CYP3A substrates and barbiturates are strong CYP3A inducers. Concomitant use of a cannabinoid product containing THC and CBD at an approximate 1:1 ratio with another strong CYP3A inducer decreased THC, 11-OH-THC, and CBD peak exposures by 36%, 87%, and 52% respectively.
Butalbital 50mg, Acetaminophen 300mg, Caffeine 40mg, Oral capsule
Grapefruit juice
· Severity: Mild
· Notes for Consumers: Do not significantly alter your grapefruit juice intake while taking medicines containing caffeine. Some reports suggest that intake of grapefruit juice can increase side effects from caffeine. Too much Caffeine can cause effects like nausea, tremor, nervousness, or sleeplessness. If these occur, consider ingesting less caffeine daily.
· Notes for Professionals: Data are limited and conflicting as to whether grapefruit juice significantly alters the serum concentrations and/or AUC of caffeine. Caffeine is primarily a CYP1A2 substrate, and grapefruit juice appears to have but a small effect on this enzyme in vivo. One report suggests that grapefruit juice decreases caffeine elimination by inhibition of flavin-containing monooxygenase, a P450 independent system. This interaction might increase caffeine levels and mildly potentiate the clinical effects and common side effects of caffeine. If side effects appear, patients may need to limit either caffeine or grapefruit juice intake.
Butalbital 50mg, Acetaminophen 300mg, Caffeine 40mg, Oral capsule
Tobacco
· Severity: Major
· Notes for Consumers: Do not smoke or use tobacco products while taking this medication. When used together, your medication may not work as well for you.
· Notes for Professionals: Advise patients who are taking caffeine to avoid smoking tobacco. Smoking tobacco has been observed to increase caffeine clearance by 50% to 70%. Caffeine is a CYP1A2 substrate and smoking tobacco induces CYP1A2.