Gabapentin, primarily prescribed for controlling seizures and managing nerve pain caused by shingles, has several off-label uses. Some of these include:
Chronic Pain Management: Gabapentin is often prescribed off-label for chronic pain conditions such as diabetic neuropathy, fibromyalgia, and chronic lower back pain.
Anxiety Disorders: Some clinicians prescribe gabapentin off-label to treat certain anxiety disorders, including generalized anxiety disorder (GAD), social anxiety disorder (SAD), and panic disorder.
Bipolar Disorder: In some cases, gabapentin may be used off-label as an adjunctive treatment for bipolar disorder, particularly for managing certain symptoms like anxiety or mood stabilization.
Insomnia: Gabapentin can be used off-label to aid in sleep and treat insomnia, especially in individuals who experience sleep disturbances due to chronic pain or anxiety.
Alcohol Withdrawal: It’s been found to be effective in managing symptoms of alcohol withdrawal, such as anxiety, agitation, and tremors, although its use in this context is not as common as other medications like benzodiazepines.
Migraine Prevention: Some studies suggest that gabapentin may be effective in preventing migraines, particularly in individuals who haven’t responded well to other medications or who experience side effects from standard migraine treatments.
Restless Legs Syndrome (RLS): Gabapentin may be used off-label to alleviate symptoms of RLS, such as uncomfortable sensations in the legs and an uncontrollable urge to move them, especially if other treatments haven’t provided relief.
Neuropathic Itch: There’s emerging evidence to suggest that gabapentin may be effective in treating neuropathic itch, a condition characterized by chronic itching due to nerve damage.
It’s important to note that using gabapentin off-label should be done under the guidance of a healthcare professional, as they can assess the risks and benefits based on individual circumstances and medical history. Off-label use means the medication hasn’t been specifically approved by regulatory agencies for these conditions, so caution should be exercised and informed consent obtained from the patient.
There are a lot of off label usage of Gabapentin in drugs.com reviews.
Gabapentin Can be used for a lot of Nerve Pain related health conditions including Cough, Hot Flashes, Alcohol Withdrawal, Anxiety 161 reviews, Bipolar Disorder, Trigeminal Neuralgia, Postherpetic Neuralgia, Migraine, Insomnia， Occipital Neuralgia， Peripheral Neuropathy，Vulvodynia, Benign Essential Tremor, Epilepsy, Fibromyalgia, Pain Relief, Diabetic Peripheral Neuropathy , Neuropathic Pain，Reflex Sympathetic Dystrophy Syndrome，Periodic Limb Movement Disorder， Spondylolisthesis， Burning Mouth Syndrome，Pudendal Neuralgia， Small Fiber Neuropathy.
Use only the brand and form of gabapentin that your doctor has prescribed. Check your medicine each time you get a refill at the pharmacy, to make sure you have received the correct form of this medication. Do not stop taking Gabapentin unless your doctor tells you to. If your treatment is stopped it should be done gradually over a minimum of 1 week. If you stop taking gabapentin suddenly or before your doctor tells you, there is an increased risk of seizures.
You can buy Neurontin at any drug store, if you have a prescription. But if you want to save your money, the best variant for you is to buy Neurontin or generic Neurontin (Gabapentin) from an online pharmacy
Neurontin is a trade mark that is owned by Pfizer company.
Gabapentin is also manufactured and marketed by other pharmaceutical companies all over the world. However it can not be marketed under the brand name Neurontin, so you can find many other medicines having absolutely the same compound, effect and safety level as Neurontin, some of those medicines are: Fanatrex, Gabarone, Gralise, Nupentin. All of these medicines are called “generics of Neurontin”.
These medicines, as they are less advertised, are much cheaper than Neurontin. However they can be hardly found at local drug stores, the only option you have, if you want to save your money and receive a high quality medicine, is to buy generic
Neurontin at our online pharmacy, which guarantees you the highest quality of the medicine, and affordable price at the same time.
When Neurontin (Gabapentin) is prescribed?
Neurontin is prescribed for the treatment of the following conditions in adults and children over 3 years:
Various forms of epilepsy. Usually doctors prescribe prescribe Neurontin for patients to help them to treat your epilepsy when a current treatment is not fully controlling his/her condition. Neurontin is used as addition to the main treatment of epilepsy.
Peripheral neuropathic pain (long lasting pain caused by damaged nerves). This disease can occur and develop in various conditions: injury, diabetes, shingles, and others.
Your doctor may prescribe you Neurontin for the treatment of other diseases, if he thinks that it is a right medicine for your case.
Before you start the treatment with Neurontin
When your doctor prescribes you Neurontin, you should necessarily inform him about the following:
If you are hypersensitive to Gabapentin
If you have any allergy
If you have any chronic or acute disease
If you are on haemodialysis
If you are taking some other medicines at the moment
If you are pregnant, breastfeeding, or plan to become pregnant or breastfeed in near future
Pharmaceutical form of Neurontin (Gabapentin)
Capsules
Neurontin is supplied in a form of capsules by 100 mg, 300 mg or 400 mg of Gabapentin.
Capsules also contain lactose monohydrate, maize starch, talc, gelatin, purified water, and sodium lauryl sulphate.
Film-Coated Tablets
Neurontin is supplied in a form of film-coated tablets by 600 mg or 800 mg of Gabapentin.
Tablets of Neurontin also contain poloxamer 407 (ethylene oxide and propylene oxide), copovidone, maize starch and magnesium stearate, opadry white YS-1-18111 (hydroxypropylcellulose, talc), candelilla wax.
Oral solution
Neurontin oral solution if supplied in bottles containing 470 ml.
Dosage of Neurontin and special recommendations
For the treatment of postherpetic neuralgia in adults, the following daily dosage is prescribed: a single 300mg dose of Neurontin on Day 1, 600 mg/day on Day 2 (divided in 2 intakes), and 900 mg day on Day 3 (divided in 3 intakes). If the effect of Neurontin is insufficient, the daily dose may be gradually increased to 1800 mg (divided in 3 intakes).
Clinical studies show that the most effective and optimal daily dosage is 1800 mg daily, doses exceeding this amount do not show improvement of the effect achieved by the daily dose of 1800 mg.
For the treatment of epilepsy, Neurontin is used in different doses for children over 3 years and for adults, the daily dose of Neurontin for adults and children over 12 years is: from 900 to 1800 mg/day taken in divided doses (three times a day), using 300 or 400 mg capsules, or 600 or 800 mg tablets. The starting dose is 300 mg three times a day.
If necessary, the daily dose may be increased using 300 or 400 mg capsules, or 600 or 800 mg tablets three times a day up to 1800 mg/day. The interval between the previous dose and increased dose should be no less than 12 hours.
For the treatment of epilepsy in children under 12 years the following dosage is prescribed: the starting dose should range from 10–15 mg/kg/day, the dose should be divided in 3 doses. In order to find the correct dose, it is recommended to increase the dose gradually in 3 days.
The optimal dose of Neurontin in patients of 5 years and older is 25–35 mg/kg/day, the maximum dose is 40mg of Neurontin taken in 3 intakes. Neurontin in children can be administered as the oral solution, capsule, or tablet, or using combinations of these formulations.
Patients with diabetes and acute renal failure should take reduced doses of Neurontin.
Neurontin is a medication that is available these days for the purpose of treating problems in relation to epilepsy. It is an anticonvulsant medication that helps you in controlling seizure symptoms. In case when you need to buy this medication, you can do that online. But you should be cautious when you buy it.
Buy this from a reputed online pharmacy store. When you take generic Neurontin there will be a cost benefit as available to you. But make sure you know that how you should take this medication and all the precautions that you need to take.
When you are on Gabapentin or Neurontin you should wear an ID card having personal info and your physicians contact number. In case of any serious complication in an emergency there can be some help that can be demanded.
Gabapentin Usage
You should use Gabapentin exactly as per your doctors advice. You should report him in case when you have some allergic reactions like hives, skin rashes and breathing problems. You should also tell your doctor if there are any side effects.
Patients having heart diseases, liver diseases and kidney diseases should be very much cautious when this medication is used. It should be taken only with doctors instructions and also there should be some amount of special medical attention that will be needed.
It is important to note that Gabapentin may give you suicidal thoughts and this can happen and you should therefore be in touch with your doctor when this medication is going on.
If you feel that the problems have worsened and there is depression, agitation, anxiety and seizures you must immediately tell your doctor about this. He may have to change the dose or at least change the medication.
It is up to the care givers to give extra attention to patients going through this phase and who are on Generic Neurontin.
It is still not known that whether this medication can be taken safely by pregnant women or not. But still, it is vital that you tell the doctor about pregnancy and plans to become pregnant so that he can guide you over the issue.
This medication can get into the blood and via that into the breast milk. Thus females who are nursing mothers should avoid generic Neurontin or Neurontin.
You should ask your doctor about all the instructions that are required to be followed when he tells you to buy this medication. You should ask about all the doubts that you have. You must also read the instruction list that comes with the medication.
It is also important to note that some doctors prescribe other medications also along with Neurontin so as to get effective treatment for the problem. It is vital to know that this epilepsy medication is not apt for children below3 years of age. The combination drugs with Neurontin are apt for children who are above 12 years of age.
If you are aware of the mentioned precautions you can take safe steps for treatment.
This medication may create a few risks for patients who are already suffering from problems like kidney, liver or heart problems. Thus if you have any such problems or you are tasking any medication in relation to these disorders then you should tell this to your doctor in advance.
You should be very specific about the scheduled appointments. Make sure that you check your doctor regularly and this is something for your safety.
If after starting the medication you feel that the problems have worsened then in that case you should be quite cautious. You should tell about this to the doctor and he will take the required action that may be needed.
Gabapentin has several potential therapeutic uses and may represent a safer option versus alternative agents in some of these indications, so the intent of this analysis is not to condemn its use.
However, it is prudent to recognize that gabapentin has seen high rates of off-label use and increased prescribing in recent years, which fails to align with current evidence regarding efficacy. Indeed, most of the evidence for off-label use is limited to a few small, low-quality studies, often with data only weakly supporting use. Higher quality evidence, which indicates gabapentin nonefficacy, is often lost in the shuffle.
Given the increasing reports of abuse and evidence of potential harms associated with gabapentin use, it is important to realize the potential risks associated with this medication and weigh these risks against this lack of reliable evidence purporting its efficacy for many of its off-label uses.
Thus, we urge clinicians to apply a more stringent appraisal of the available evidence for a given indication when prescribing gabapentin off-label and call for larger, higher-quality studies to be conducted to better assess the efficacy of gabapentin for many of its off-label uses.
Not many people are aware of the medical condition that is known as Diabetic Neuropathy however more and more people are being diagnosed with having it, and if you have been recently diagnosed with Diabetic Neuropathy then you will need to start to take drug to help manage and control that condition.
The best drug you can take is the fast acting Gabapentin and one of the main reasons why many people who do have Diabetic Neuropathy will take that drug is that it is not only fast acting as mentioned but it is also a very low cost drug to purchase too.
Please do spend some time researching more information on Diabetic Neuropathy for when you do you will find that the very best course of action will be first to get that condition diagnosed by a Doctor and then the best treatment available will be by you then taking Gabapentin regularly to control that condition.
You will also be best advised to also spend a few minutes watching the following video that is going to explain to you more about Diabetic Neuropathy including the Types, Symptoms, Prevention and Treatment of Diabetic Neuropathy which you will certainly find very informative and educational too.
Also please do be aware that we do have a range of other articles and guides dotted around this website that will also give you additional information on a range of similar medical conditions that you may be suffering from or experiencing, so please do spend as much time as you like looking around our website as all of that information is free to access.
We also update our website continually with other related news stories and articles so do consider bookmarking this website and checking back regularly too.
If you do want to take Gabapentin to treat diabetic neuropathy then please do be aware there can be some side effects, and before you make a purchase of Gabapentin you will be best advised to find out what the side effect of Gabapentin when taking it to treat diabetic neuropathy, and if at any time you start to experience any of those side effects then please seek the advice of a Doctor or a medical professional.
There are going to be plenty of places online that you can buy Gabapentin, however when you make the very wise decision of using us as your official suppler of Gabapentin you are guaranteed of having the very lowest prices available to you and also as an approved stockist you will of course always be guaranteed of receiving genuine Gabapentin too.
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Gabapentin in the treatment of painful diabetic neuropathy: a placebo controlled, double blind, crossover trial [1]
Painful neuropathy is a common and disabling problem in patients with longstanding diabetes mellitus. Tricyclic antidepressant drugs and other chronic analgesics have been beneficial in some patients,1 but no agent successfully relieves pain in most patients and adverse effects often preclude their use in high doses.
Anecdotal reports suggest that gabapentin ameliorates pain associated with neuropathy and other neurological conditions with few side effects. We conducted a randomised, double blind, placebo controlled trial to study the effect of low dose gabapentin in patients with painful diabetic neuropathy.
We recruited 40 patients with painful diabetic neuropathy who had (1) diabetes for at least 6 months on a stable dosage of insulin or oral hypoglycaemic agent, (2) distal symmetric sensorimotor neuropathy as shown by impaired pin prick, temperature, or vibration sensation in both feet and absent or reduced ankle reflexes, and (3) daily neuropathic pain in the acral extremities, of at least moderate severity, for over 3 months that interfered with daily activity or sleep. Excluded were those with diabetes and chronic renal insufficiency, painful diabetic plexopathy, or lumbosacral polyradiculopathy, peripheral vascular disease, another painful condition, or other cause for neuropathy. Patients were randomly assigned to gabapentin (300 mg capsules) or placebo for 6 weeks (phase I) followed by a 3 week washout period and then crossover (phase II).
The dose of gabapentin or placebo was increased by one capsule every 3 days to a stable dosage of one capsule three times daily (900 mg/day) that was maintained throughout the remainder of the treatment period. The low dosage of gabapentin was chosen to minimise adverse effects that might compromise blinding. Treatment with stable dosages of non-steroidal anti-inflammatory agents or narcotics were permitted during the trial but patients discontinued all other chronic analgesic medications 3 weeks before study entry.
At the beginning and end of each treatment period, patients rated their level of pain over the preceding 24 hours on a 10 cm visual anologue pain scale (VAS), ranging from 0 (“no pain”) to 10 (“worst pain ever”). Present pain intensity (PPI, “rate how much pain you have at this moment,” using a similar 0–10 scale) and the McGill pain questionnaire (MPQ) were recorded at the initial and final visits of each treatment period.
At the end of each treatment period patients provided a global assessment of pain relief: none, mild, moderate, or excellent, as compared with the level of pain preceding each treatment period. The global assessment of pain relief was dichotomised (none/mild vmoderate/excellent) for purposes of analysis. The protocol was approved by the Institutional Review Board at St Elizabeth’s Medical Center and all patients gave written informed consent.
There were 31 men and nine women, with an average age of 62 years (SD 10.9 years, range 43–82 years). All but one had adult onset diabetes mellitus, with a mean duration of 14 years (SD 9.9 years, range 6 months-40 years). Ten had neuropathic pain limited to the feet, 19 had pain in the feet and legs, and 11 had pain in the feet, legs, and hands. The mean duration of neuropathic pain was 4 years (SD 3.5 years, range 4 months-15 years). Twenty five had previously used narcotics or other chronic analgesics to manage their pain.
Nineteen patients were randomised to the active drug and 21 to placebo during the first treatment period. The mean reduction in the MPQ score was 8.9 points with gabapentin compared with 2.2 points with placebo (p=0.03, two sample t test). There were no differences in the mean change of the VAS or PPI scores between gabapentin and placebo (table).
Fourteen patients reported moderate or excellent pain relief with gabapentin only, six with placebo only, and three with both; 17 reported none or mild relief after both treatments (p=0.11, McNemar’s test). There were no serious adverse events. Adverse effects were significantly more common with gabapentin (12 patients) compared with placebo (four patients, p<0.001, McNemar’s test). The most common side effects of gabapentin were drowsiness (six patients), fatigue (four), and imbalance (three). All adverse effects resolved promptly after discontinuation of the drug.
Comparison of mean change in pain scales between gabapentin and placebo
Anecdotal reports suggest that gabapentin has beneficial effects in patients with various painful neurological conditions, including HIV neuropathy,2 postherpetic neuralgia,2 and reflex sympathetic dystrophy.3 The mechanism of action of gabapentin in ameliorating pain is unknown, but animal studies suggest that its pain modulating properties may be linked to the release of the neurotransmitter GABA in spinal cord pathways that modify pain perception.
There was statistical improvement in only one of four end points, the MPQ score, with gabapentin compared with placebo. The MPQ is a valid, consistent, and reliable measure of subjective pain experience, and usually correlates with other measures of pain intensity, including the VAS and PPI scales.4 We designed the study to have an 80% power to detect a 20% reduction in pain scores, reflecting a modest but clinically important improvement.
The mean change of the VAS and PPI scales and the patient’s global assessment of pain relief were not significantly different from placebo. We used a crossover design because of its statistical efficiency, but the MPQ and VAS scores did not return to baseline after crossover in patients who received gabapentin in phase I (the washout period was inadequate); therefore, we may have underestimated improvement with gabapentin in the VAS scale that may have been detected using a parallel group design.
Furthermore, a limitation of our study was that quantitative measures (for example, nerve conduction studies, quantitative sensory thresholds) were not used to further characterise the type of neuropathy. Because of the heterogeneous nature of neuropathic pain in our study patients, we may not have identified a subset of patients who improved with gabapentin. Alternatively, the dosage of gabapentin may have been too low to induce analgesia in patients with painful diabetic neuropathy, although similar regimens have been reported to be effective in patients with other painful conditions.
The results of this study suggest that gabapentin is probably ineffective or only minimally effective for the treatment of painful diabetic neuropathy at a dosage of 900 mg/day.
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What is Gabapentin ?
Gabapentin is used with other medications to prevent and control seizures. It is also used to relieve nerve pain following shingles (a painful rash due to herpes zoster infection) in adults.
Gabapentin is known as an anticonvulsant or antiepileptic drug.
gabapentin forms and strength
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
Gabapentin may also be used to treat other nerve pain conditions (such as diabetic neuropathy, peripheral neuropathy, trigeminal neuralgia) and restless legs syndrome.
Gabapentin is an anti-epileptic medication, also called an anticonvulsant. It affects chemicals and nerves in the body that are involved in the cause of seizures and some types of pain.
Gabapentin is used in adults to treat nerve pain caused by herpes virus or shingles (herpes zoster).
The Horizant brand is also used to treat restless legs syndrome (RLS).
The Neurontin brand is also used to treat seizures in adults and children who are at least 3 years old.
Use only the brand and form of gabapentin that your doctor has prescribed. Check your medicine each time you get a refill at the pharmacy, to make sure you have received the correct form of this medication.
Gabapentin may also be used for purposes not listed in this medication guide.
How should I take gabapentin?
Take gabapentin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
The Horizant brand of gabapentin should not be taken during the day. For best results, take Horizant with food at about 5:00 in the evening.
Both Gralise and Horizant should be taken with food.
Neurontin can be taken with or without food.
If you break a Neurontin tablet and take one half of it, take the other half at your next dose. Any tablet that has been broken should be used as soon as possible or within a few days.
Measure liquid medicine with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
If your doctor changes your brand, strength, or type of gabapentin, your dosage needs may change. Ask your pharmacist if you have any questions about the new brand you receive at the pharmacy.
Do not stop using gabapentin suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor’s instructions about tapering your dose.
Wear a medical alert tag or carry an ID card stating that you take gabapentin. Any medical care provider who treats you should know that you take seizure medication.
This medication can cause you to have a false positive urine protein screening test. If you provide a urine sample for testing, tell the laboratory staff that you are taking gabapentin.
Store at room temperature away from light and moisture.
Store the liquid medicine in the refrigerator. Do not freeze.
Gabapentin Can be used for a lot of Nerve Pain related health conditions including Cough, Hot Flashes, Alcohol Withdrawal, Anxiety 161 reviews, Bipolar Disorder, Trigeminal Neuralgia, Postherpetic Neuralgia, Migraine, Insomnia? Occipital Neuralgia? Peripheral Neuropathy?Vulvodynia, Benign Essential Tremor, Epilepsy, Fibromyalgia, Pain Relief, Diabetic Peripheral Neuropathy , Neuropathic Pain?Reflex Sympathetic Dystrophy Syndrome?Periodic Limb Movement Disorder? Spondylolisthesis? Burning Mouth Syndrome?Pudendal Neuralgia? Small Fiber Neuropathy.
Use only the brand and form of gabapentin that your doctor has prescribed. Check your medicine each time you get a refill at the pharmacy, to make sure you have received the correct form of this medication. Do not stop taking Gabapentin unless your doctor tells you to. If your treatment is stopped it should be done gradually over a minimum of 1 week. If you stop taking gabapentin suddenly or before your doctor tells you, there is an increased risk of seizures.
the ingredients in NEURONTIN
The active ingredient in NEURONTIN capsules, tablets, and oral solution is gabapentin,which has the chemical name 1-(aminomethyl)cyclohexaneacetic acid.
The molecular formula of gabapentin is C9H17NO2 and the molecular weight is 171.24. The structural formula of gabapentin is:
Gabapentin is a white to off-white crystalline solid with a pKa1 of 3.7 and a pKa2 of 10.7. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is –1.25.
Each Neurontin capsule contains 100 mg, 300 mg, or 400 mg of gabapentin and the following inactive ingredients: lactose, cornstarch, talc, gelatin, titanium dioxide, FD&C Blue No. 2, yellow iron oxide (300 mg and 400 mg only), and red iron oxide (400 mg only).
Each Neurontin tablet contains 600 mg or 800 mg of gabapentin and the following inactive ingredients: poloxamer 407, copovidone, cornstarch, magnesium stearate, hydroxypropyl cellulose, talc, and candelilla wax
Neurontin oral solution contains 250 mg of gabapentin per 5 mL (50 mg per mL) and the following inactive ingredients: glycerin, xylitol, purified water, and artificial cool strawberry anise flavor.
Gabapentin Mechanism of action
The chemical structure of gabapentin (Neurontin) is derived by addition of a cyclohexyl group to the backbone of gamma-aminobutyric acid (GABA). Gabapentin prevents seizures in a wide variety of models in animals, including generalized tonic-clonic and partial seizures. Gabapentin has no activity at GABAA or GABAB receptors of GABA uptake carriers of brain.
Gabapentin interacts with a high-affinity binding site in brain membranes, which has recently been identified as an auxiliary subunit of voltage-sensitive Ca2+ channels. However, the functional correlate of gabapentin binding is unclear and remains under study. Gabapentin crosses several lipid membrane barriers via system L amino acid transporters.
In vitro, gabapentin modulates the action of the GABA synthetic enzyme, glutamic acid decarboxylase (GAD) and the glutamate synthesizing enzyme, branched-chain amino acid transaminase. Results with human and rat brain NMR spectroscopy indicate that gabapentin increases GABA synthesis. Gabapentin increases non-synaptic GABA responses from neuronal tissues in vitro. In vitro, gabapentin reduces the release of several mono-amine neurotransmitters.
Gabapentin prevents pain responses in several animal models of hyperalgesia and prevents neuronal death in vitro and in vivo with models of the neurodegenerative disease amyotrophic lateral sclerosis (ALS).
Gabapentin is also active in models that detect anxiolytic activity. Although gabapentin may have several different pharmacological actions, it appears that modulation of GABA synthesis and glutamate synthesis may be important.
Who is not suitable for Ordering Gabapentin Online ?
Normally Gabapentin is suitable for all adult and children bigger than six years old. But you are not allowed to order Gabapentin online if you have any of following health conditions (But you are OK to order in your local street pharmacies):
You are younger than 18 years old;
You have kidney disease;
diabetes;
liver disease and heart diseases;
a history of depression, mood disorder, drug abuse, or suicidal thoughts or actions;
(for patients with RLS) if you are a day sleeper or work a night shift;
You are breastfeeding mother or you are pregnant;
have thoughts about suicide.
Stop immediately if you have any thoughts about suicide. Donot order Gabapentin online if you have suicide thoughts. Please go to your doctor to have your completely checked.
FDA Warnings
The U.S. Food and Drug Administration (FDA) is warning that serious breathing difficulties may occur in patients using gabapentin (Neurontin, Gralise, Horizant) or pregabalin (Lyrica, Lyrica CR) who have respiratory risk factors. These include the use of opioid pain medicines and other drugs that depress the central nervous system, and conditions such as chronic obstructive pulmonary disease (COPD) that reduce lung function. The elderly are also at higher risk.
Gabapentin and pregabalin are FDA-approved for a variety of conditions, including seizures, nerve pain, and restless legs syndrome.
Our evaluation shows that the use of these medicines, often referred to as gabapentinoids, has been growing for prescribed medical use, as well as misuse and abuse. Gabapentinoids are often being combined with CNS depressants, which increases the risk of respiratory depression. CNS depressants include opioids, anti-anxiety medicines, antidepressants, and antihistamines. There is less evidence supporting the risk of serious breathing difficulties in healthy individuals taking gabapentinoids alone. We will continue to monitor these medicines as part of our routine monitoring of all FDA-approved drugs.
What are gabapentinoids and how can they help me?
Gabapentinoids are FDA-approved to treat a variety of conditions including partial seizures and nerve pain from spinal cord injury, shingles, and diabetes. Other approved uses include fibromyalgia and restless legs syndrome. Gabapentin was first approved in 1993 and pregabalin was first approved in 2004. Gabapentin is marketed under the brand names Neurontin and Gralise, and also as generics. Gabapentin enacarbil is marketed under the brand name Horizant. Pregabalin is marketed under the brand names Lyrica and Lyrica CR, and also as generics. Pregabalin is a Schedule V controlled substance, which means it has a lower potential for abuse among the drugs scheduled by the Drug Enforcement Administration (DEA), but may lead to some physical or psychological dependence.
What is the risk to take Gabapentin ?
All medicines have side effects even when used correctly as prescribed, but in general the benefits of taking a medicine outweigh these risks. It is important to know that people respond differently to all medicines depending on their health, other medicines they are taking, the diseases they have, genetics, and many other factors. As a result, we cannot determine the likelihood that someone will experience these side effects when taking gabapentinoids. Your personal health care professional knows you best, so always tell them about all other medicines you are taking and if you experience any side effects while taking your medicines.
Gabapentin side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Gabapentin: hives; fever; swollen glands; painful sores in or around your eyes or mouth; difficulty breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
increased seizures;
fever, swollen glands, body aches, flu symptoms;
skin rash, easy bruising or bleeding, severe tingling, numbness, pain, muscle weakness;
upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);
chest pain, irregular heart rhythm, feeling short of breath;
confusion, nausea and vomiting, swelling, rapid weight gain, urinating less than usual or not at all;
new or worsening cough, fever, trouble breathing;
rapid back and forth movement of your eyes; or
severe skin reaction — fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Some side effects are more likely in children taking gabapentin. Contact your doctor if the child taking this medication has any of the following side effects:
changes in behavior;
memory problems;
trouble concentrating; or
acting restless, hostile, or aggressive.
Common gabapentin side effects may include:
dizziness, drowsiness;
dry mouth, blurred vision;
headache;
diarrhea; or
swelling in your hands or feet.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Gabapentin Withdrawal
Gabapentin withdrawal occurs when stopping use of the drug after becoming physically dependent on it. It is possible to become physically dependent on gabapentin even when using the medication only as prescribed, particularly if it is used on a long-term basis.
Symptoms of withdrawal typically begin within 12 hours of the last drug use and may last up to a week. If gabapentin is being used to treat a seizure disorder, stopping use of the drug too suddenly can cause the frequency of seizures to increase.
Gabapentin can cause changes in mood and may trigger depressive episodes, as well as compulsive thoughts. Withdrawal can also trigger mood episodes and other mental health problems, including anxiety and suicidal ideation. This is more likely in young adults and children. These symptoms of gabapentin withdrawal can last longer than acute physical symptoms, sometimes lasting weeks or months.
There are currently no FDA-approved medications for the treatment of gabapentin withdrawal. Some withdrawal symptoms, such as nausea and pain, may be treated with medications specifically for those symptoms. The main treatment for gabapentin withdrawal is supportive medical care and behavioral interventions. If an addiction is present, withdrawal may be the first step in the recovery process from a substance use disorder.
Gabapentin is an Addiction Treatment Medication
Gabapentin is used to treat cases of addiction in an off-label manner. Different companies, including Parke-Davis, Greenstone, and Teva, manufacture several varieties of the generic drug. Other drugs that have been used to treat the symptoms of addiction withdrawal, for specific substances, include:
Clondine
Other anticonvulsants, such as Tegretol and Depakote
Methadone and buprenorphine
Naltrexone
Typical Application
Available in capsules, tablets, and as an oral liquid, dosages range from 100 mg to 800 mg. The frequency with which a dose is repeated depends on the specific dose, which is usually based on the severity of withdrawal and the client’s weight. The drug’s half-life is around 5-7 hours.
Generally, it is used during medical detox and throughout subsequent treatment modalities to support relapse prevention while clients adjust to their new sober lifestyles.
Treating Substance Abuse
According to Medscape, gabapentin can inflict users with suicidal thoughts and abrupt changes in behavior. For this reason, it should only be used under medical supervision. It can also cause elevated blood pressure, fever, sleep problems, appetite changes, and chest pain.
While it has been used to treat addictions to other substances, gabapentin is most often used to treat alcoholism — an addiction some 16.6 million adults suffered from in 2013, per the National Institute on Alcohol Abuse and Alcoholism.
During withdrawal from alcohol abuse or dependency, clients may experience anxiety, tremors, agitation, and irritability. In order to understand how gabapentin works, there must be a basic understanding of how the brain works first. Nervous system activity is partially controlled by GABA neurotransmitters. Gabapentin works by reducing activity among GABA. As a result, signals for pain, agitation, and anxiety are reduced, too.
An American Journal of Psychiatry study showed impressive results during the 16-week treatment of 150 people who were dependent on alcohol, noting better results among those who were treated with both gabapentin and naltrexone than the latter alone. TheJournal of Clinical Psychiatry reported on another study in which individuals treated for alcoholism with gabapentin showed a significant reduction in how much they drank and a greater rate of abstinence than those in the placebo group.
Gabapentin has the same calming effect on individuals who are detoxing from marijuana and benzodiazepines. Despite claims from fans of the plant-based drug, marijuana is indeed addictive. In 2012, 305,560 people checked into rehab citing cannabis as their primary drug of abuse, per the Substance Abuse and Mental Health Services Administration. One Neuropsychopharmacology study that analyzed the use of gabapentin in the treatment of marijuana addiction and withdrawal noted individuals in the gabapentin treatment group used less marijuana, had fewer withdrawal symptoms, and experienced improvements in cognitive functioning, compared to the placebo group.
Gabapentin is the generic name of a prescription drug used to treat epilepsy. Gabapentin works by decreasing abnormal excitement in the brain. It also may change the way the body senses pain. Gabapentin is in a class of medications called anticonvulsants.
Gabapentin is a medication that is commonly used to help control various types of pain. While its primary indication is for the treatment of epilepsy and seizures, it has also been found to be effective in managing certain types of neuropathic pain, including:
Diabetic Neuropathy: Gabapentin can help reduce the pain associated with diabetic neuropathy, which is nerve damage caused by diabetes.
Postherpetic Neuralgia: Gabapentin is often prescribed to relieve the pain that persists after an episode of shingles (herpes zoster).
Neuropathic Pain: Gabapentin may also be used to alleviate neuropathic pain associated with other conditions, such as spinal cord injury, multiple sclerosis, and fibromyalgia.
Chronic Pain Syndromes: In some cases, gabapentin may be used off-label to manage chronic pain syndromes, such as chronic lower back pain or chronic regional pain syndrome (CRPS).
Gabapentin works by modulating the activity of neurotransmitters in the brain, particularly gamma-aminobutyric acid (GABA), which helps reduce abnormal neuronal firing and dampens pain signals. While it may not be effective for all types of pain, gabapentin can provide significant relief for some individuals with neuropathic pain conditions.
Gabapentin is primarily used to help manage pain, particularly neuropathic pain, by altering the way the body perceives pain signals. However, it does not cure the underlying condition causing the pain.
For example, if someone has neuropathic pain due to diabetic neuropathy or postherpetic neuralgia (nerve pain following shingles), gabapentin can help reduce the intensity of the pain signals being sent to the brain. This can result in a decrease in pain sensations and improved quality of life for the individual. However, it doesn’t address the root cause of the neuropathy itself.
It’s important for individuals using gabapentin for pain management to understand that it is part of a comprehensive treatment plan that may also include physical therapy, lifestyle modifications, and other medications. Additionally, some individuals may find that gabapentin provides significant relief from their pain, while others may not experience the same level of benefit.
As always, it’s essential to work closely with a healthcare provider to determine the most appropriate treatment plan for managing pain and to monitor for any potential side effects or complications associated with gabapentin use.
The U.S. Food and Drug Administration (FDA) approved gabapentin in 1993 under the brand name Neurontin for the drug manufacturer Pfizer. The medication comes in capsule form, as a regular or extended-release tablet, and as a liquid.
Gabapentin interacts with voltage-sensitive calcium channels in cortical neurons. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters.
gabapentin
One of the mechanisms implicated in this effect of gabapentin is the reduction of the axon excitability measured as an amplitude change of the presynaptic fibre volley (FV) in the CA1 area of the hippocampus.
This is mediated through its binding to presynaptic NMDA receptors. Other studies have shown that the antihyperalgesic and antiallodynic effects of gabapentin are mediated by the descending noradrenergic system, resulting in the activation of spinal alpha-2 adrenergic receptors. Gabapentin has also been shown to bind and activate the adenosine A1 receptor.
Gabapentin may help to control your condition but will not cure it. Continue to take gabapentin even if you feel well. Do not stop taking gabapentin without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood.
If you suddenly stop taking gabapentin tablets, capsules, or oral solution, you may experience withdrawal symptoms such as anxiety, difficulty falling asleep or staying asleep, nausea, pain, and sweating. If you are taking gabapentin to treat seizures and you suddenly stop taking the medication, you may experience seizures more often.
Your doctor may decrease your dose gradually over at least a week.
Yes, you can buy Gabapentin Online! You still need a prescription to buy Gabapentin online, though. Fortunately, you can get a Gabapentin prescription online from a licensed and qualified doctor.
Gabapentin, known sometimes by the generic name Neurontin, is primarily used to diffuse the symptoms of epilepsy. When used as an analgesic or painkiller, Gabapentin acts through a different mechanism than commonly prescribed pain medicines such as morphine and oxycontin. Due to this, Gabapentin is thought to be less addictive than opiates – but addiction and abuse may still occur.
PubChem, an NCBI branch, defines “Gabapentin [as] a synthetic analog of the neurotransmitter gamma-aminobutyric acid with anticonvulsant activity. Although its exact mechanism of action is unknown, Gabapentin appears to inhibit excitatory neuron activity. This agent also exhibits analgesic properties. (NCI04)”
Gabapentin Side Effects
Contact your doctor if you experience anything unusual while taking any medication.
Most common Gabapentin side effects:
Tiredness
Dizziness
Headache
Common Gabapentin side effects:
Fatigue
Double vision
Blurred vision
Tremors
Less common Gabapentin side effects:
Increased appetite
Weight gain
Arm or leg swelling
Back pain
Upset stomach
Intestinal gas
Dry mouth or throat
Constipation
Dental problems
Muscle aches
Runny nose
Sore throat
Speech problems
Memory loss
Depression
Sleep problems
Irritability
Abnormal thinking
Twitching
Itching
Abrasions
Impotence
Visual disturbance
Anxiety
Panic attacks
Rare Gabapentin side effects:
Dizziness
Depression
Suicidal thoughts
Seizure
Reduced sex drive
Broken bones
Poor coordination
Low red- and white- blood cell counts
Flushing
Allergic reactions, such as swelling, fever, rash, itching, and trouble breathing
Gabapentin Precautions
You should not take Gabapentin if you are allergic or sensitive to any of its ingredients. It is not recommended to drink alcohol while taking Gabapentin as it may cause more drowsiness than usual. Doctors often recommend abstaining from alcohol completely during the first few days of treatment while figuring out how the drug affects you.
This medication has been associated with seizure development in people without epilepsy. Typically those individuals were taking other medication such as antidepressants, antipsychotics, stimulants, or narcotics.
In the unlikely event that a seizure occurs in an individual who has not experienced a seizure before, a doctor needs to evaluate the individual for an underlying seizure disorder. Contact your doctor immediately (before your next dose) as they likely will need to modify your treatment plan.
Suddenly stopping any antiepileptic drug, including Gabapentin, can increase the chance of seizures, so don’t stop taking it if you are waiting for your doctor to become available.
Special Information on Gabapentin
Gabapentin may make you feel dizzy or tired or interfere with your concentration. Exhibit extreme caution when driving or performing other tasks requiring careful attention.
Alcohol and other depressants are not recommended because it increases dizzy and tired effects.
Contact your doctor if you experience worsening symptoms of depression, suicidal thoughts, panic attacks, anxiety, agitation, restlessness, trouble sleeping, reckless behavior, or any other bothersome or persistent side effects.
Gabapentin Dosage
Adult and child (age 13 and over): 300 – 600 milligrams 3 times a day. Dosage may need to be reduced in individuals with kidney disease.
Child (age 3 – 12) 4.5-7 milligrams per lb. of body weight a day in 3 divided doses to start, increasing gradually for about 3 days to a maximum dosage of 22 milligrams per lb. a day in divided doses.
Child (under the age of 3): not recommended
Gabapentin for Seniors
Seniors may need to take a lower dosage due to decreased kidney function. Make your doctor aware of potential kidney disorders during your evaluation so they can account for that when determining the correct dosage for you.
How To Take Gabapentin
Take Gabapentin exactly as prescribed by your doctor. Do not use prescription doses from someone you know who is taking it.
You can take Gabapentin with or without food. If you experience nausea or stomach discomfort after taking Gabapentin, try eating a small meal before taking your next dose.
Avoid taking Gabapentin along with an antacid, such as Pepto-Bismol or Maalox, as the antacid will interfere with absorption. You can still take antacids, but separate the dose from Gabapentin by at least two hours.
If you forget a dose of Gabapentin, take it as soon as you remember. If it is almost time for your next dose, take the dose you forgot and space the remaining doses evenly throughout the day. Do not take a double dose.
If you are unsure how to take medicine, do not hesitate to contact your healthcare provider or pharmacist. They have received extensive training on answering questions such as a forgotten dose.
Do You Need a Prescription for Gabapentin?
Yes, you need a prescription for Gabapentin. Gabapentin is classified as a controlled substance in:
Kentucky
Tennessee
Virginia
West Virginia
Michigan
This means you will need to see a doctor in person for a Gabapentin prescription in those states.
If you live elsewhere you will be able to get Gabapentin from an online doctor, like those at our sister site PlushCare.
How Can I Get a Prescription for Gabapentin?
To get a prescription for Gabapentin, a doctor must evaluate you for a disorder. Then the doctor will evaluate potential treatment options and decide whether the risk to benefit ratio of Gabapentin is favorable in your case.
An increasingly popular option for getting prescriptions is going to an online doctor. EverydayDr recommends PlushCare for these types of services. They have same-day access to medical professionals across the country, all of whom have graduated from a top-50 medical institution. You can book an appointment quickly and see a doctor in as little as 15 minutes.
PlushCare is a great platform to get a Gabapentin prescription online. If you live in a state where Gabapentin is not classified as a controlled substance and the doctor decides Gabapentin is an appropriate treatment for you, they will electronically send your prescription to the pharmacy of your choice.
How much does a 30 day supply of Gabapentin cost?
The price of a 30 day supply of Gabapentin varies widely depending on location, dosage, and insurance status. Gabapentin is a widely used drug and is typically covered by insurance.
If you don’t have insurance or your provider does not cover this medication, Gabapentin is available for only $0.19 per 300 milligrams capsule (as of January 2021). An adult taking 300 milligrams three times a day should expect a cost of $17.10 per 30 day supply.
You may be able to save a few dollars by checking the price at multiple local and online pharmacies. Costs of medication are always subject to change.
Gabapentin While Pregnant/Breastfeeding
Gabapentin causes congenital disabilities in laboratory animals. Seizure disorders are known to be associated with increased congenital disabilities in humans. Your doctor will have to weigh the risk of experiencing seizures during pregnancy and the benefit of reducing seizures during pregnancy to decide if taking this medication is right for you.
It is not known if Gabapentin passes into breast milk. Nursing mothers are strongly encouraged to use formula to err on the side of caution.
If you suddenly stop taking gabapentin tablets, capsules, or oral solution, you may experience withdrawal symptoms such as anxiety, difficulty falling asleep or staying asleep, nausea, pain, and sweating. If you are taking gabapentin to treat seizures and you suddenly stop taking the medication, you may experience seizures more often.